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발행년 : 2014 
구분 : 국내학술지 
학술지명 : 대한내과학회지 (The Korean Journal of Medicine) 
관련링크 : http://www.riss.kr/link?id=A99887971 
특집 : 조혈모세포이식을 위한 최적의 제대혈 선택 지침
= Special Review : Optimal Selection of Cord Blood for Hematopoietic Stem Cell Transplantation

                                    

  • 저자명

    유건희 ( Keon Hee Yoo )                                                       

  • 학술지명

    대한내과학회지 (The Korean Journal of Medicine)              

  • 권호사항

    Vol.86 No.1 [2014]                                                         

  • 발행처

    대한내과학회                              

  • 발행처 URL

    http://www.kaim.or.kr

  • 자료유형

    학술저널

  • 수록면

    14-19(6쪽)

  • 언어

    Korean

  • 발행년도

    2014년

  • 등재정보

    KCI등재

  • KCI 피인용횟수

    0                                                                                     

  • 초록 (Abstract)
    • Umbilical cord blood (CB) has been an alternative hematopoietic stem cell source especially for patients without an appropriate marrow or mobilized peripheral blood donor. Although many studies have shown similar overall survival rates after CB transp...
  • Umbilical cord blood (CB) has been an alternative hematopoietic stem cell source especially for patients without an appropriate marrow or mobilized peripheral blood donor. Although many studies have shown similar overall survival rates after CB transplantation compared with other donor sources, higher rate of non-relapse mortality is a major obstacle for a successful CB transplantation. Thus, selecting a best appropriate unit is very important to improve the outcome of CB transplantation. Adequate cell dose and better HLA matching (antigen-level for -A, -B, and allele-level for -DRB1) have been considered most important criteria of donor choice for CB transplantation. In recent, other criteria including non-inherited maternal antigens, HLA-C matching, allele-level matching at 8 loci (-A, -B, -C, -DRB1), and anti-HLA antibodies are also suggested as factors that might affect the outcome of CB transplantation. This review will highlight current issues regarding criteria of donor choice for CB transplantation. Finally, I will introduce the algorithm and detailed guideline for CB selection recently developed in Korea, which may help physicians to choose best unit available. (Korean J Med 2014;86:14-19)
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