[동향] Unexpected mutations after CRISPR–Cas9 editing in vivo
| 발행년 | 2017 |
|---|---|
| 키워드 | 유전체편집, 유전자가위, 실험동물, 크리스퍼,genome editing |
| 관련링크 | https://www.nature.com/nmeth/journal/v14....4293.html |
참고 기사 “유전자 가위, ‘표적 벗어난 변이’ 예상보다 많이 발생” http://scienceon.hani.co.kr/522774
Unexpected mutations after CRISPR–Cas9 editing in vivo
- Nature Methods
- 14,
- 547–548
- doi:10.1038/nmeth.4293
- Published online
CRISPR–Cas9 editing shows promise for correcting disease-causing mutations. For example, in a recent study we used CRISPR-Cas9 for sight restoration in blind rd1 mice by correcting a mutation in the Pde6b gene1. However, concerns persist regarding secondary mutations in regions not targeted by the single guide RNA (sgRNA)2.…
